| First Author | de Wit E | Year | 2011 |
| Journal | J Infect Dis | Volume | 204 Suppl 3 |
| Pages | S968-72 | PubMed ID | 21987777 |
| Mgi Jnum | J:294094 | Mgi Id | MGI:6451376 |
| Doi | 10.1093/infdis/jir330 | Citation | de Wit E, et al. (2011) Assessment of rodents as animal models for Reston ebolavirus. J Infect Dis 204 Suppl 3:S968-72 |
| abstractText | The emergence of Reston ebolavirus (REBOV) in domestic swine in the Philippines has caused a renewed interest in REBOV pathogenicity. Here, the use of different rodent species as animal disease models for REBOV was investigated. BALB/c and STAT1(-)(/-) mice, Hartley guinea pigs, and Syrian hamsters were inoculated intraperitoneally with REBOV strain Pennsylvania or Reston08-A. Although virus replication occurred in guinea pigs, hamsters, and STAT1(-/-) mice, progression to disease was only observed in STAT1(-)(/-) mice. Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-)(/-) mice may be used for research of REBOV pathogenicity and intervention strategies. |
