| First Author | Lechner AJ | Year | 2017 |
| Journal | Cell Stem Cell | Volume | 21 |
| Issue | 1 | Pages | 120-134.e7 |
| PubMed ID | 28506464 | Mgi Jnum | J:253970 |
| Mgi Id | MGI:6101275 | Doi | 10.1016/j.stem.2017.03.024 |
| Citation | Lechner AJ, et al. (2017) Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell 21(1):120-134.e7 |
| abstractText | To investigate the role of immune cells in lung regeneration, we used a unilateral pneumonectomy model that promotes the formation of new alveoli in the remaining lobes. Immunofluorescence and single-cell RNA sequencing found CD115+ and CCR2+ monocytes and M2-like macrophages accumulating in the lung during the peak of type 2 alveolar epithelial stem cell (AEC2) proliferation. Genetic loss of function in mice and adoptive transfer studies revealed that bone marrow-derived macrophages (BMDMs) traffic to the lung through a CCL2-CCR2 chemokine axis and are required for optimal lung regeneration, along with Il4ra-expressing leukocytes. Our data suggest that these cells modulate AEC2 proliferation and differentiation. Finally, we provide evidence that group 2 innate lymphoid cells are a source of IL-13, which promotes lung regeneration. Together, our data highlight the potential for immunomodulatory therapies to stimulate alveologenesis in adults. |
