| First Author | Rezende RM | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 8726 | PubMed ID | 26644347 |
| Mgi Jnum | J:234036 | Mgi Id | MGI:5788813 |
| Doi | 10.1038/ncomms9726 | Citation | Rezende RM, et al. (2015) Identification and characterization of latency-associated peptide-expressing gammadelta T cells. Nat Commun 6:8726 |
| abstractText | gammadelta T cells are a subset of lymphocytes specialized in protecting the host against pathogens and tumours. Here we describe a subset of regulatory gammadelta T cells that express the latency-associated peptide (LAP), a membrane-bound TGF-beta1. Thymic CD27+IFN-gamma+CCR9+alpha4beta7+TCRgammadelta+ cells migrate to the periphery, particularly to Peyer's patches and small intestine lamina propria, where they upregulate LAP, downregulate IFN-gamma via ATF-3 expression and acquire a regulatory phenotype. TCRgammadelta+LAP+ cells express antigen presentation molecules and function as antigen presenting cells that induce CD4+Foxp3+ regulatory T cells, although TCRgammadelta+LAP+ cells do not themselves express Foxp3. Identification of TCRgammadelta+LAP+ regulatory cells provides an avenue for understanding immune regulation and biologic processes linked to intestinal function and disease. |
