| First Author | Fu YY | Year | 2019 |
| Journal | Immunity | Volume | 51 |
| Issue | 1 | Pages | 90-103.e3 |
| PubMed ID | 31278057 | Mgi Jnum | J:282408 |
| Mgi Id | MGI:6380830 | Doi | 10.1016/j.immuni.2019.06.003 |
| Citation | Fu YY, et al. (2019) T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation. Immunity 51(1):90-103.e3 |
| abstractText | The key sites within the gastrointestinal (GI) tract where T cells mediate effector responses and the impact of these responses on intestinal stem cells (ISCs) remain unclear. Using experimental bone marrow transplantation to model immune-mediated GI damage and 3D imaging to analyze T cell localization, we found that the ISC compartment is the primary intestinal site targeted by T cells after transplantation. Recruitment to the crypt base region resulted in direct T cell engagement with the stem cell compartment and loss of crypt base columnar ISCs, which expressed both MHC classes I and II. Vasculature expressing the adhesion molecule MAdCAM-1 clustered near the crypt base, preferentially regulating crypt compartment invasion and ISC reduction without affecting T cell migration to villi. These findings indicate that allogeneic T cells rapidly access the stem cell niche after transplantation, and this targeted recruitment to the stem cell compartment results in ISC loss during immune-mediated GI damage. |
