| First Author | Porter T | Year | 2019 |
| Journal | Neurobiol Aging | Volume | 76 |
| Pages | 162-165 | PubMed ID | 30716541 |
| Mgi Jnum | J:276163 | Mgi Id | MGI:6313963 |
| Doi | 10.1016/j.neurobiolaging.2018.12.014 | Citation | Porter T, et al. (2019) Klotho allele status is not associated with Abeta and APOE epsilon4-related cognitive decline in preclinical Alzheimer's disease. Neurobiol Aging 76:162-165 |
| abstractText | The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-beta (Abeta) burden, and carriage of the apolipoprotein E (APOE) epsilon4 allele on cognitive decline. This study involved 581 Abeta-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Abeta burden and APOE epsilon4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Abeta burden and APOE epsilon4-driven cognitive decline in preclinical AD. |
