| First Author | Matossian-Rogers A | Year | 1983 |
| Journal | Immunogenetics | Volume | 18 |
| Issue | 6 | Pages | 639-48 |
| PubMed ID | 6228526 | Mgi Jnum | J:7273 |
| Mgi Id | MGI:55744 | Doi | 10.1007/BF00345971 |
| Citation | Matossian-Rogers A, et al. (1983) Alloimmune interactions of a lymphoproliferative disease-inducer gene Arp and linkage to Pep-7. Immunogenetics 18(6):639-48 |
| abstractText | In this report we describe a new diallelic gene system, Arpa and Arpb, which codes for surface antigens on murine lymphocytes. Arpb is present only in a mutant strain of BALB/c which is designated BALB/c-Arpb. Normal BALB/c and all other strains of mice tested express Arpa. The Arpb mutation is associated with a newly discovered polymorphism of the Peptidase-7 enzyme, Pep-7b, which codes for a variant form of the enzyme with a faster anodal mobility on electrophoresis than the commonly known form. The Arp locus controls a range of alloimmune interactions between Arp incompatible lymphocytes. These include mixed lymphocyte reactivity, host-versus-graft and graft-versus-host reactions and the development of weak cytotoxic but strong cytostatic effector lymphocytes which are allo- as well as autoreactive. The association between Arp and Pep-7 and the biological significance of the Arp locus are discussed. |
