| First Author | Cordes S | Year | 2008 |
| Journal | Brain Res | Volume | 1227 |
| Pages | 120-7 | PubMed ID | 18602902 |
| Mgi Jnum | J:139724 | Mgi Id | MGI:3809987 |
| Doi | 10.1016/j.brainres.2008.06.043 | Citation | Cordes S, et al. (2008) Intact interval timing in circadian CLOCK mutants. Brain Res 1227:120-7 |
| abstractText | While progress has been made in determining the molecular basis for the circadian clock, the mechanism by which mammalian brains time intervals measured in seconds to minutes remains a mystery. An obvious question is whether the interval-timing mechanism shares molecular machinery with the circadian timing mechanism. In the current study, we trained circadian CLOCK +/- and -/- mutant male mice in a peak-interval procedure with 10 and 20-s criteria. The mutant mice were more active than their wild-type littermates, but there were no reliable deficits in the accuracy or precision of their timing as compared with wild-type littermates. This suggests that expression of the CLOCK protein is not necessary for normal interval timing. |
