| First Author | Walker JK | Year | 2006 |
| Journal | Am J Respir Cell Mol Biol | Volume | 34 |
| Issue | 6 | Pages | 711-8 |
| PubMed ID | 16474097 | Mgi Jnum | J:122615 |
| Mgi Id | MGI:3714882 | Doi | 10.1165/rcmb.2005-0314OC |
| Citation | Walker JK, et al. (2006) Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. Am J Respir Cell Mol Biol 34(6):711-8 |
| abstractText | Asthma is a ubiquitous disease with a broad range of clinical phenotypes. To better understand the complex genetic and environmental interactions underlying asthma, we compared the gene-gene interactions of four genetically distinct mouse strains that demonstrate biologically distinct responses to allergen. Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the development of ovalbumin-induced allergic airway inflammatory disease. In addition, gene expression profiling data have revealed other potential novel targets for therapeutics-based research and has enhanced the understanding of the molecular mechanisms underlying the etiology of 'asthma.' |
