| First Author | Maher K | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 5 | Pages | 720-6 |
| PubMed ID | 24462687 | Mgi Jnum | J:206662 |
| Mgi Id | MGI:5551664 | Doi | 10.1016/j.febslet.2014.01.015 |
| Citation | Maher K, et al. (2014) Decreased IL-10 expression in stefin B-deficient macrophages is regulated by the MAP kinase and STAT-3 signaling pathways. FEBS Lett 588(5):720-6 |
| abstractText | Innate immune responses are tightly regulated to avoid excessive activation and subsequent inflammatory damage to the host, and interleukin-10 (IL-10) plays a crucial role in preventing inflammation. Stefin B (cystatin B) is an endogenous inhibitor of cysteine proteinases. In stefin B-deficient bone marrow-derived macrophages (BMDMs), we detected an increase in the induction of the LPS-induced pro-inflammatory signal nitric oxide (NO) but decreased IL-10 expression. The phosphorylation of ERK and p38 MAP-kinases was significantly decreased in stefin B-deficient macrophages, as was STAT-3 phosphorylation. These findings show that stefin B influences the expression of anti-inflammatory IL-10 in response to the TLR4 agonist LPS. |
