| First Author | Obata Y | Year | 2014 |
| Journal | EMBO Rep | Volume | 15 |
| Issue | 12 | Pages | 1297-304 |
| PubMed ID | 25378482 | Mgi Jnum | J:217542 |
| Mgi Id | MGI:5614518 | Doi | 10.15252/embr.201438942 |
| Citation | Obata Y, et al. (2014) Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues. EMBO Rep 15(12):1297-304 |
| abstractText | Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj-a gene encoding a transcription factor implicated in Notch signaling-in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down-regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE. |
