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Publication : Erythropoietin Stimulates Tumor Growth via EphB4.

First Author	Pradeep S	Year	2015
Journal	Cancer Cell	Volume	28
Issue	5	Pages	610-622
PubMed ID	26481148	Mgi Jnum	J:226762
Mgi Id	MGI:5698546	Doi	10.1016/j.ccell.2015.09.008
Citation	Pradeep S, et al. (2015) Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell 28(5):610-22

abstractText

While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo's effects on cancer cells prompted us to consider the existence of an alternative Epo receptor. Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor growth and progression. In human ovarian and breast cancer samples, expression of EphB4 rather than the canonical EpoR correlated with decreased disease-specific survival in rhEpo-treated patients. These results identify EphB4 as a critical mediator of erythropoietin-induced tumor progression and further provide clinically significant dimension to the biology of erythropoietin.

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