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Publication : Erythropoietin Stimulates Tumor Growth via EphB4.

First Author  Pradeep S Year  2015
Journal  Cancer Cell Volume  28
Issue  5 Pages  610-622
PubMed ID  26481148 Mgi Jnum  J:226762
Mgi Id  MGI:5698546 Doi  10.1016/j.ccell.2015.09.008
Citation  Pradeep S, et al. (2015) Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell 28(5):610-22
abstractText  While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo's effects on cancer cells prompted us to consider the existence of an alternative Epo receptor. Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor growth and progression. In human ovarian and breast cancer samples, expression of EphB4 rather than the canonical EpoR correlated with decreased disease-specific survival in rhEpo-treated patients. These results identify EphB4 as a critical mediator of erythropoietin-induced tumor progression and further provide clinically significant dimension to the biology of erythropoietin.
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