| First Author | Adachi M | Year | 1995 |
| Journal | Nat Genet | Volume | 11 |
| Issue | 3 | Pages | 294-300 |
| PubMed ID | 7581453 | Mgi Jnum | J:64296 |
| Mgi Id | MGI:1889065 | Doi | 10.1038/ng1195-294 |
| Citation | Adachi M, et al. (1995) Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet 11(3):294-300 |
| abstractText | Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (lpr) mutation is a leaky mutation in Fas. By means of gene targeting, we generated a mouse strain which is completely deficient in Fas. In addition to the massive production of lymphocytes, the Fas-null mice showed substantial liver hyperplasia, which was accompanied by the enlargement of nuclei in hepatocytes. The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs. |
