| First Author | Nimmerjahn F | Year | 2010 |
| Journal | Proc Natl Acad Sci U S A | Volume | 107 |
| Issue | 45 | Pages | 19396-401 |
| PubMed ID | 20974962 | Mgi Jnum | J:167375 |
| Mgi Id | MGI:4868145 | Doi | 10.1073/pnas.1014515107 |
| Citation | Nimmerjahn F, et al. (2010) FcgammaRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo. Proc Natl Acad Sci U S A 107(45):19396-401 |
| abstractText | Cellular Fcgamma receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fcgamma receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in FcgammaRIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating FcgammaRs. To study the role of individual activating FcgammaRs for IgG subclass activity, we generated an FcgammaRIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity. |
