| First Author | Montandon G | Year | 2017 |
| Journal | Sci Rep | Volume | 7 |
| Issue | 1 | Pages | 18105 |
| PubMed ID | 29273726 | Mgi Jnum | J:287509 |
| Mgi Id | MGI:6407647 | Doi | 10.1038/s41598-017-17379-x |
| Citation | Montandon G, et al. (2017) delta-Subunit Containing GABAA Receptors Modulate Respiratory Networks. Sci Rep 7(1):18105 |
| abstractText | Persistent and stable respiratory activity across behavioral states is key to homeostasis. Extrasynaptic delta-subunit containing GABAA receptors (deltaGABAARs) mediate tonic inhibition and regulate network activity. However, the influence of deltaGABAARs on respiratory rhythm and motor outputs is unknown. We manipulated extra-synaptic GABAA receptor function in the preBotzinger Complex (preBotC), a site central to the generation of inspiratory motor activity in mammals. Activation of preBotC deltaGABAARs in anesthetized rats and wild-type mice decreased breathing rate. In deltaGABAAR knockout (Gabrd (-/-)) mice, however, deltaGABAARs activation had no effect on breathing rate. We then found that during active wakefulness associated with behaviors and movements, diaphragm activation was higher in the Gabrd (-/-) compared to wild-type mice, but not in other states. These findings identify that deltaGABAARs modulate the respiratory network, which is critical to understand how deltaGABAARs change breathing in pathological conditions affecting extra-synaptic GABAA receptor function such as exposure to anesthetics and neurosteroids. |
