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Allele : Gt(ROSA)26Sor<tm1Sho> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Stuart Orkin
Primary Identifier  MGI:1861931 Allele Type  Targeted
Attribute String  Conditional ready, Reporter Gene  Gt(ROSA)26Sor
Inheritance Mode  Not Specified Transmission  Germline
Strain of Origin  129S4/SvJaeSor Is Recombinase  false
Is Wild Type  false
description  Mice carrying this mutation are considered to be reporter strains, with successful Cre excision indicated by beta-gal expression in Cre-expressing tissues.
molecularNote  A targeting vector was designed to insert floxed (flanked by loxP) phosphoglycerate kinase-1-cytosine deaminase/phosphoglycerate kinase-1-puromycin (PGK-CD/PGK-Puro) and stop sequences between the splicing acceptor (SA) and the beta-gal-neomycin phosphotransferase fusion gene (beta-geo) sequences of the proviral ROSA 26 locus. Correctly targeted, this resulted in ES cells that were Puro resistant but G418 susceptible, and did not express beta-gal.
  • mutations:
  • Insertion
  • synonyms:
  • ROSA26-loxP-stoploxP-beta-geo,
  • Rosa26<fsLz>,
  • gtROSA,
  • ROSA26R-LacZ reporter,
  • Rosa26<fsLz>,
  • ROSA26-stop-lacZ,
  • ROSA26R-LacZ reporter,
  • R26RstoplacZ,
  • ROSA26-stop-lacZ,
  • ROSA26-loxP-stoploxP-beta-geo,
  • R26Rosa-lox-Stop-lox-LacZ,
  • R26RstoplacZ,
  • R26-beta-gal<fl-STOP>,
  • R26R,
  • Rosa26<fsLz>,
  • R26R,
  • R26<fslz>,
  • gtROSA,
  • R26Rosa-lox-Stop-lox-LacZ,
  • R26-beta-gal<fl-STOP>,
  • R26<fslz>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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4 Carried By

0 Driven By

110 Publication categories





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