| First Author | de Alborán IM | Year | 2004 |
| Journal | Cell Death Differ | Volume | 11 |
| Issue | 1 | Pages | 61-8 |
| PubMed ID | 12970677 | Mgi Jnum | J:115648 |
| Mgi Id | MGI:3692035 | Doi | 10.1038/sj.cdd.4401319 |
| Citation | de Alboran IM, et al. (2004) c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death. Cell Death Differ 11(1):61-8 |
| abstractText | C-myc gene is a member of the myc family of proto-oncogenes involved in proliferation, differentiation, and apoptosis. Overexpression of c-myc in fibroblasts causes apoptosis under low serum conditions in a process that requires the interaction of CD95 and CD95L on the surface. We have previously reported an in vivo conditional model to inactivate the c-myc gene in B lymphocytes. Here, we show that c-Myc-deficient primary B lymphocytes are resistant to different apoptotic stimuli. Nonactivated c-Myc-deficient B cells are resistant to spontaneous cell death. Upon activation, c-Myc-deficient B lymphocytes express normal surface levels of activation markers, and show resistance to staurosporine and CD95-induced cell death. |
