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Publication : Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin.

First Author  Tian Y Year  2004
Journal  Dev Dyn Volume  231
Issue  1 Pages  199-203
PubMed ID  15305300 Mgi Jnum  J:91732
Mgi Id  MGI:3050279 Doi  10.1002/dvdy.20106
Citation  Tian Y, et al. (2004) Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin. Dev Dyn 231(1):199-203
abstractText  We made a transgenic mouse that expresses Cre recombinase activity in inner ear hair cells by using a modified bacterial artificial chromosome containing Prestin. Cre recombinase activity was restricted to inner and outer hair cells, a subset of vestibular hair cells, spiral and vestibular ganglia in the inner ear, and a subset of cells in the testis, epididymis, and ear bone. This mouse will be useful for hair-cell-specific gene targeting.
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