| First Author | Tang SH | Year | 2002 |
| Journal | Genesis | Volume | 32 |
| Issue | 3 | Pages | 199-202 |
| PubMed ID | 11892008 | Mgi Jnum | J:75826 |
| Mgi Id | MGI:2177898 | Doi | 10.1002/gene.10030 |
| Citation | Tang SH, et al. (2002) A cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ. Genesis 32(3):199-202 |
| abstractText | Summary: A Cre recombinase expression cassette was inserted into the X-linked Hprt locus by gene targeting in a mouse embryonic stem (ES) cell line isogenic to strain 129S1/SvImJ (129S1), then the transgene was introduced into 129S1 mice through ES cell chimeras. When females hemizygous for this transgene were mated to males carrying a neomycin selection cassette flanked by loxP sites, the cassette was always excised regardless of Cre inheritance and without detectable mosaicism. The usefulness of this 'Cre-deleter' transgenic line is in its efficiency and defined genetic status in terms of mouse strain and location of the transgene. genesis 32:199-202, 2002. Copyright 2002 Wiley-Liss, Inc. |
