| First Author | Ding W | Year | 2024 |
| Journal | Cell Rep | Volume | 43 |
| Issue | 4 | Pages | 113990 |
| PubMed ID | 38551964 | Mgi Jnum | J:347900 |
| Mgi Id | MGI:7627917 | Doi | 10.1016/j.celrep.2024.113990 |
| Citation | Ding W, et al. (2024) Nausea-induced suppression of feeding is mediated by central amygdala Dlk1-expressing neurons. Cell Rep 43(4):113990 |
| abstractText | The motivation to eat is suppressed by satiety and aversive stimuli such as nausea. The neural circuit mechanisms of appetite suppression by nausea are not well understood. Pkcdelta neurons in the lateral subdivision of the central amygdala (CeA) suppress feeding in response to satiety signals and nausea. Here, we characterized neurons enriched in the medial subdivision (CeM) of the CeA marked by expression of Dlk1. CeA(Dlk1) neurons are activated by nausea, but not satiety, and specifically suppress feeding induced by nausea. Artificial activation of CeA(Dlk1) neurons suppresses drinking and social interactions, suggesting a broader function in attenuating motivational behavior. CeA(Dlk1) neurons form projections to many brain regions and exert their anorexigenic activity by inhibition of neurons of the parabrachial nucleus. CeA(Dlk1) neurons are inhibited by appetitive CeA neurons, but also receive long-range monosynaptic inputs from multiple brain regions. Our results illustrate a CeA circuit that regulates nausea-induced feeding suppression. |
