| First Author | Nyeng P | Year | 2019 |
| Journal | Dev Cell | Volume | 49 |
| Issue | 1 | Pages | 31-47.e9 |
| PubMed ID | 30853440 | Mgi Jnum | J:284168 |
| Mgi Id | MGI:6390658 | Doi | 10.1016/j.devcel.2019.02.005 |
| Citation | Nyeng P, et al. (2019) p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate. Dev Cell 49(1):31-47.e9 |
| abstractText | The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these two apparently opposing models, demonstrating that pancreatic progenitors re-localize to establish the niche that will determine their ultimate fate. We identify a p120ctn-regulated mechanism for coordination of organ architecture and cellular fate mediated by differential E-cadherin based cell sorting. Reduced p120ctn expression is necessary and sufficient to re-localize a subset of progenitors to the peripheral tip domain, where they acquire an acinar fate. The same mechanism is used re-iteratively during endocrine specification, where it balances the choice between the alpha and beta cell fates. In conclusion, organ patterning is regulated by p120ctn-mediated cellular positioning, which precedes and determines pancreatic progenitor fate. |
