| First Author | Liu H | Year | 2011 |
| Journal | Genesis | Volume | 49 |
| Issue | 8 | Pages | 689-95 |
| PubMed ID | 21786403 | Mgi Jnum | J:175778 |
| Mgi Id | MGI:5287312 | Doi | 10.1002/dvg.20741 |
| Citation | Liu H, et al. (2011) Stella-Cre mice are highly efficient Cre deleters. Genesis 49(8):689-95 |
| abstractText | Cre-loxP recombination is widely used for genetic manipulation of the mouse genome. Here, we report generation and characterization of a new Cre line, Stella-Cre, where Cre expression cassette was targeted to the 3' UTR of the Stella locus. Stella is specifically expressed in preimplantation embryos and in the germline. Cre-loxP recombination efficiency in Stella-Cre mice was investigated at several genomic loci including Rosa26, Jak2, and Npm1. At all the loci examined, we observed 100% Cre-loxP recombination efficiency in the embryos and in the germline. Thus, Stella-Cre mice serve as a very efficient deleter line. |
