| First Author | Choudhary B | Year | 2009 |
| Journal | Genesis | Volume | 47 |
| Issue | 2 | Pages | 115-21 |
| PubMed ID | 19165826 | Mgi Jnum | J:147389 |
| Mgi Id | MGI:3840416 | Doi | 10.1002/dvg.20466 |
| Citation | Choudhary B, et al. (2009) Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis 47(2):115-21 |
| abstractText | To address the requirement for TGFbeta signaling in the formation and maintenance of the vascular matrix, we employed lineage-specific mutation of the type II TGFbeta receptor gene (Tgfbr2) in vascular smooth muscle precursors in mice. In both neural crest- and mesoderm-derived smooth muscle, absence of TGFbeta receptor function resulted in a poorly organized vascular elastic matrix in late-stage embryos which was prone to dilation and aneurysm. This defect represents a failure to initiate formation of the elastic matrix, rather than a failure to maintain a preexisting matrix. In mutant tissue, lysyl oxidase expression was substantially reduced, which may contribute to the observed pathology. |
