| First Author | Yamanaka K | Year | 2008 |
| Journal | Nat Neurosci | Volume | 11 |
| Issue | 3 | Pages | 251-3 |
| PubMed ID | 18246065 | Mgi Jnum | J:135268 |
| Mgi Id | MGI:3790925 | Doi | 10.1038/nn2047 |
| Citation | Yamanaka K, et al. (2008) Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 11(3):251-3 |
| abstractText | Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease that is characterized by the loss of motor neurons. Using mice carrying a deletable mutant gene, diminished mutant expression in astrocytes did not affect onset, but delayed microglial activation and sharply slowed later disease progression. These findings demonstrate that mutant astrocytes are viable targets for therapies for slowing the progression of non-cell autonomous killing of motor neurons in ALS. |
