| First Author | de Lange FJ | Year | 2003 |
| Journal | Genesis | Volume | 37 |
| Issue | 1 | Pages | 1-4 |
| PubMed ID | 14502570 | Mgi Jnum | J:86158 |
| Mgi Id | MGI:2678888 | Doi | 10.1002/gene.10220 |
| Citation | de Lange FJ, et al. (2003) Atrial cardiomyocyte-specific expression of Cre recombinase driven by an Nppa gene fragment. Genesis 37(1):1-4 |
| abstractText | To study the development of the atria, we produced a transgenic mouse line that expresses Cre under the regulatory control of a 7 kbp fragment of the Natriuretic peptide precursor type A gene (Nppa), from -3 kbp to +4 kbp relative to the transcription start site. Crossing this line with the R26R and Z/EG reporter lines revealed recombinase activity specifically in the cardiomyocytes of the atria and to a lesser extent the inflow tract from E10.5 onwards. At E14.5 recombination in the atria is almost complete. No recombination was observed outside the heart. These mice provide a tool to study gene function in the atria. |
