| First Author | van den Bout CJ | Year | 2002 |
| Journal | Mech Dev | Volume | 110 |
| Issue | 1-2 | Pages | 179-82 |
| PubMed ID | 11744379 | Mgi Jnum | J:73807 |
| Mgi Id | MGI:2156906 | Doi | 10.1016/s0925-4773(01)00597-4 |
| Citation | van den Bout CJ, et al. (2002) The mouse enhancer element D6 directs Cre recombinase activity in the neocortex and the hippocampus. Mech Dev 110(1-2):179-82 |
| abstractText | We have created a transgenic mouse line that expresses Cre recombinase under the control of the novel mouse promoter/enhancer D6. We describe the expression pattern of D6-Cre in a Gtrosa26 reporter background as assayed by LacZ activity. The enhancer activity starts at 10.5 days post-coitum in the telencephalon and is at the later embryonic stages highly restricted to the hippocampus and the neocortex. In adult mice D6-derived cells are found in cortical layers II-VI, in the granular cells of the dentate gyrus and in hippocampal fields CA1-CA3. D6-Cre activity is also detected in the ependymal and subependymal zone of the lateral ventricles which is known to harbor neural stem cells. |
