| First Author | Zhu M | Year | 2008 |
| Journal | Osteoarthritis Cartilage | Volume | 16 |
| Issue | 1 | Pages | 129-30 |
| PubMed ID | 17888690 | Mgi Jnum | J:225347 |
| Mgi Id | MGI:5693139 | Doi | 10.1016/j.joca.2007.08.001 |
| Citation | Zhu M, et al. (2008) Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice. Osteoarthritis Cartilage 16(1):129-30 |
| abstractText | OBJECTIVE: To determine the specificity and efficiency of the tamoxifen (TM)-induced Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice. METHODS: Col2a1-CreER(T2) transgenic mice were bred with Rosa26 reporter mice. Two-week-old Col2a1-CreER(T2);R26R mice were administered TM for 5 days and were sacrificed 1 and 6 months after TM induction. X-Gal staining was performed. RESULTS: Efficient Cre-recombination is achieved in adult articular chondrocytes 1 and 6 months after TM induction. CONCLUSION: Our findings demonstrate that the Col2a1-CreER(T2) transgenic mouse model is a valuable tool to target genes specifically expressed in articular chondrocytes in a temporally controlled manner in adult mice. |
