| First Author | Trueman RC | Year | 2008 |
| Journal | Behav Brain Res | Volume | 189 |
| Issue | 2 | Pages | 317-24 |
| PubMed ID | 18367261 | Mgi Jnum | J:133206 |
| Mgi Id | MGI:3778099 | Doi | 10.1016/j.bbr.2008.01.020 |
| Citation | Trueman RC, et al. (2008) Time course of choice reaction time deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease in the operant Serial Implicit Learning Task (SILT). Behav Brain Res 189(2):317-24 |
| abstractText | A range of transgenic and knock-in mouse models of Huntington's disease have been created since identification in 1993 of the disease mutation in the HD gene. Knock-in models that express the full-length mutant protein tend to exhibit less severe behavioural deficits than transgenic models and so require more sensitive tasks in order to reveal impairments. To achieve this, we therefore used a Serial Implicit Learning Task (SILT), which measures serial reaction times to visual stimuli, requiring detection and responding in both predictable and unpredictable locations in the 9-hole operant chamber. We have previously reported that knock-in Hdh(Q92/Q92) mice exhibit a modest impairment in learning the SILT tasks at 4 months of age, prior to the formation of overt neuronal nuclear inclusions. In the present study we have explored the time course of the development of impairments from 5 to 14 months of age. The deficit previously found in accuracy and reaction time was present at all ages examined in these Hdh(Q92/Q92) mice; the deficit was not progressive, and did not correlate with the evolution of neuronal nuclear inclusions. |
