| First Author | Srinivasan L | Year | 2009 |
| Journal | Cell | Volume | 139 |
| Issue | 3 | Pages | 573-86 |
| PubMed ID | 19879843 | Mgi Jnum | J:157297 |
| Mgi Id | MGI:4430534 | Doi | 10.1016/j.cell.2009.08.041 |
| Citation | Srinivasan L, et al. (2009) PI3 kinase signals BCR-dependent mature B cell survival. Cell 139(3):573-86 |
| abstractText | Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role. |
