| First Author | Zaretsky I | Year | 2017 |
| Journal | J Exp Med | Volume | 214 |
| Issue | 11 | Pages | 3435-3448 |
| PubMed ID | 28939548 | Mgi Jnum | J:250274 |
| Mgi Id | MGI:5922148 | Doi | 10.1084/jem.20171129 |
| Citation | Zaretsky I, et al. (2017) ICAMs support B cell interactions with T follicular helper cells and promote clonal selection. J Exp Med 214(11):3435-3448 |
| abstractText | The germinal center (GC) reaction begins with a diverse and expanded group of B cell clones bearing a wide range of antibody affinities. During GC colonization, B cells engage in long-lasting interactions with T follicular helper (Tfh) cells, a process that depends on antigen uptake and antigen presentation to the Tfh cells. How long-lasting T-B interactions and B cell clonal expansion are regulated by antigen presentation remains unclear. Here, we use in vivo B cell competition models and intravital imaging to examine the adhesive mechanisms governing B cell selection for GC colonization. We find that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate Tfh-B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion. Thus, B cell ICAMs promote efficient antibody immune response by enhancement of T cell help to cognate B cells. |
