| First Author | Jacobsen EA | Year | 2011 |
| Journal | J Immunol | Volume | 187 |
| Issue | 11 | Pages | 6059-68 |
| PubMed ID | 22048766 | Mgi Jnum | J:179701 |
| Mgi Id | MGI:5302910 | Doi | 10.4049/jimmunol.1102299 |
| Citation | Jacobsen EA, et al. (2011) Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation. J Immunol 187(11):6059-68 |
| abstractText | Reports have recently suggested that eosinophils have the potential to modulate allergen-dependent pulmonary immune responses. The studies presented expand these reports demonstrating in the mouse that eosinophils are required for the allergen-dependent Th2 pulmonary immune responses mediated by dendritic cells (DCs) and T lymphocytes. Specifically, the recruitment of peripheral eosinophils to the pulmonary lymphatic compartment(s) was required for the accumulation of myeloid DCs in draining lymph nodes and, in turn, Ag-specific T effector cell production. These effects on DCs and Ag-specific T cells did not require MHC class II expression on eosinophils, suggesting that these granulocytes have an accessory role as opposed to direct T cell stimulation. The data also showed that eosinophils uniquely suppress the DC-mediated production of Th17 and, to smaller degree, Th1 responses. The cumulative effect of these eosinophil-dependent immune mechanisms is to promote the Th2 polarization characteristic of the pulmonary microenvironment after allergen challenge. |
