| First Author | Wu CA | Year | 2010 |
| Journal | Cell Immunol | Volume | 264 |
| Issue | 1 | Pages | 32-41 |
| PubMed ID | 20494340 | Mgi Jnum | J:162110 |
| Mgi Id | MGI:4462757 | Doi | 10.1016/j.cellimm.2010.04.008 |
| Citation | Wu CA, et al. (2010) Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways. Cell Immunol 264(1):32-41 |
| abstractText | IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naive bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD), produced elevated levels of IL-5 mRNA and protein as compared to BEC from naive mice. To determine the contribution of BEC-derived IL-5 to effector responses in the airways, IL-5 deficient bone marrow chimeric mice were generated in which IL-5 expression was restricted to stromal (e.g. BEC) or hematopoietic cells. When subjected to AAD, IL-5 produced by BECs contributed to mucous metaplasia, airway eosinophilia, and OVA-specific IgA levels. Thus, IL-5 production by BEC can impact the microenvironment of the lung, modifying pathologic and protective immune responses in the airways. |
