| First Author | Colling SB | Year | 1996 |
| Journal | Neurosci Lett | Volume | 209 |
| Issue | 1 | Pages | 49-52 |
| PubMed ID | 8734907 | Mgi Jnum | J:36183 |
| Mgi Id | MGI:83621 | Doi | 10.1016/0304-3940(96)12596-9 |
| Citation | Colling SB, et al. (1996) Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents. Neurosci Lett 209(1):49-52 |
| abstractText | The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that CA(2+)-activated K+ currents, in particular IAHP, are disrupted in PrP-null mice. |
