| First Author | Jouvin-Marche E | Year | 2006 |
| Journal | J Immunol | Volume | 176 |
| Issue | 6 | Pages | 3490-7 |
| PubMed ID | 16517717 | Mgi Jnum | J:129512 |
| Mgi Id | MGI:3769603 | Doi | 10.4049/jimmunol.176.6.3490 |
| Citation | Jouvin-Marche E, et al. (2006) Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus. J Immunol 176(6):3490-7 |
| abstractText | Cellular prion protein (PrP(C)) is an ubiquitously expressed glycoprotein whose roles are still widely discussed, particularly in the field of immunology. Using TgA20- and Tg33-transgenic mice overexpressing PrP(C), we investigated the consequences of this overexpression on T cell development. In both models, overexpression of PrP(C) induces strong alterations at different steps of T cell maturation. On TgA20 mice, we observed that these alterations are cell autonomous and lead to a decrease of alphabeta T cells and a concomitant increase of gammadelta T cell numbers. PrP(C) has been shown to bind and chelate copper and, interestingly, under a copper supplementation diet, TgA20 mice presented a partial restoration of the alphabeta T cell development, suggesting that PrP(C) overexpression, by chelating copper, generates an antioxidant context differentially impacting on alphabeta and gammadelta T cell lineage. |
