| First Author | Kudo W | Year | 2012 |
| Journal | Hum Mol Genet | Volume | 21 |
| Issue | 5 | Pages | 1138-44 |
| PubMed ID | 22100763 | Mgi Jnum | J:180597 |
| Mgi Id | MGI:5306689 | Doi | 10.1093/hmg/ddr542 |
| Citation | Kudo W, et al. (2012) Cellular prion protein is essential for oligomeric amyloid-beta-induced neuronal cell death. Hum Mol Genet 21(5):1138-44 |
| abstractText | In Alzheimer disease (AD), amyloid-beta (Abeta) oligomer is suggested to play a critical role in imitating neurodegeneration, although its pathogenic mechanism remains to be determined. Recently, the cellular prion protein (PrP(C)) has been reported to be an essential co-factor in mediating the neurotoxic effect of Abeta oligomer. However, these previous studies focused on the synaptic plasticity in either the presence or the absence of PrP(C) and no study to date has reported whether PrP(C) is required for the neuronal cell death, the most critical element of neurodegeneration in AD. Here, we show that Prnp(-/-) mice are resistant to the neurotoxic effect of Abeta oligomer in vivo and in vitro. Furthermore, application of an anti-PrP(C) antibody or PrP(C) peptide prevents Abeta oligomer-induced neurotoxicity. These findings are the first to demonstrate that PrP(C) is required for Abeta oligomer-induced neuronal cell death, the pathology essential to cognitive loss. |
