| First Author | Benavides F | Year | 1999 |
| Journal | Immunogenetics | Volume | 49 |
| Issue | 5 | Pages | 413-9 |
| PubMed ID | 10199917 | Mgi Jnum | J:54856 |
| Mgi Id | MGI:1336387 | Doi | 10.1007/s002510050514 |
| Citation | Benavides F, et al. (1999) Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency. Immunogenetics 49(5):413-9 |
| abstractText | A spontaneous recessive mutation named nackt (symbol: nkt) affecting hair growth and T-cell development was discovered in a moderately inbred stock of mice. Skin lesions were characterized by sparse rough coat, bare patches around the eyes and neck, and a scratching behavior throughout life. Fluorescence-activated cell sorter analysis indicated a deficiency in the CD4(+) 8(-) T-cell subset in the thymus and a marked decrease in CD4(+) T cells in peripheral lymphoid organs. Linkage analysis using a set of molecular markers and an F-2 intersubspecific cross indicated that the mutation maps to the central region of mouse chromosome 13, in a region homologous to human chromosome 5q22-q35. |
