| First Author | Fu A | Year | 2022 |
| Journal | Cell | Volume | 185 |
| Issue | 8 | Pages | 1356-1372.e26 |
| PubMed ID | 35395179 | Mgi Jnum | J:353659 |
| Mgi Id | MGI:7266584 | Doi | 10.1016/j.cell.2022.02.027 |
| Citation | Fu A, et al. (2022) Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer. Cell 185(8):1356-1372.e26 |
| abstractText | Tumor-resident intracellular microbiota is an emerging tumor component that has been documented for a variety of cancer types with unclear biological functions. Here, we explored the functional significance of these intratumor bacteria, primarily using a murine spontaneous breast-tumor model MMTV-PyMT. We found that depletion of intratumor bacteria significantly reduced lung metastasis without affecting primary tumor growth. During metastatic colonization, intratumor bacteria carried by circulating tumor cells promoted host-cell survival by enhancing resistance to fluid shear stress by reorganizing actin cytoskeleton. We further showed that intratumor administration of selected bacteria strains isolated from tumor-resident microbiota promoted metastasis in two murine tumor models with significantly different levels of metastasis potential. Our findings suggest that tumor-resident microbiota, albeit at low biomass, play an important role in promoting cancer metastasis, intervention of which might therefore be worth exploring for advancing oncology care. |
