| First Author | Toomey JR | Year | 1997 |
| Journal | Proc Natl Acad Sci U S A | Volume | 94 |
| Issue | 13 | Pages | 6922-6 |
| PubMed ID | 9192667 | Mgi Jnum | J:41500 |
| Mgi Id | MGI:893978 | Doi | 10.1073/pnas.94.13.6922 |
| Citation | Toomey JR, et al. (1997) Effect of tissue factor deficiency on mouse and tumor development. Proc Natl Acad Sci U S A 94(13):6922-6 |
| abstractText | Previous reports suggest that tissue factor (TF) may play an essential role in embryonic vascular development and tumor angiogenesis. To further examine this relationship, the morphology of fully developed TF-deficient embryos and the growth of TF-deficient teratomas and teratocarcinomas were analyzed. In a 129/Sv genetic background, TF null embryos do not survive beyond mid-gestation. In contrast, 14% of 129/Sv x C57BL/6 TF-deficient embryos escape this early mortality and survive to birth. On gross and microscopic inspection, these late gestation, TF-deficient embryos appear normal. The growth and vascularity of TF(+/+), TF(+/-), and TF(-/-) teratomas and teratocarcinomas are indistinguishable. Thus, tumor-derived TF is not required for tumor growth and angiogenesis and the combined data do not support an essential role for TF in embryonic vascular development. |
