| First Author | Guttenplan KA | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 3753 |
| PubMed ID | 32719333 | Mgi Jnum | J:292273 |
| Mgi Id | MGI:6447175 | Doi | 10.1038/s41467-020-17514-9 |
| Citation | Guttenplan KA, et al. (2020) Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model. Nat Commun 11(1):3753 |
| abstractText | Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We previously defined a mechanism by which microglia release three factors, IL-1alpha, TNFalpha, and C1q, to induce neurotoxic astrocytes. Here we report that knocking out these three factors markedly extends survival in the SOD1(G93A) ALS mouse model, providing evidence for gliosis as a potential ALS therapeutic target. |
