| First Author | Mark DA | Year | 2000 |
| Journal | Am J Respir Cell Mol Biol | Volume | 22 |
| Issue | 3 | Pages | 265-71 |
| PubMed ID | 10696062 | Mgi Jnum | J:114244 |
| Mgi Id | MGI:3688656 | Doi | 10.1165/ajrcmb.22.3.3747 |
| Citation | Mark DA, et al. (2000) B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. Am J Respir Cell Mol Biol 22(3):265-71 |
| abstractText | We examined the roles of B7-1 (CD80) and B7-2 (CD86) in a model of allergic pulmonary inflammation and airway hyperresponsiveness (AHR) by using mice with germline deletions of the B7-1 and/or B7-2 molecules. Multiple parameters of the allergic response were affected to varying degrees by the absence of B7-1 and/or B7-2. Mice lacking both B7-1 and B7-2 had no elevation of serum immunoglobulin E, lack of airway eosinophilia, and no AHR. These same disease parameters were also reduced in mice lacking either B7-1 or B7-2. Lack of B7-1 and/or B7-2 resulted in an increase in T-helper 1 cytokine production. Our observations suggest that whereas B7-2 is quantitatively more significant in the induction of this response, B7-1 and B7-2 may have complementary roles in mediating the development of allergic pulmonary inflammation. |
