| First Author | Liu Z | Year | 2009 |
| Journal | J Immunol | Volume | 183 |
| Issue | 10 | Pages | 6320-9 |
| PubMed ID | 19880450 | Mgi Jnum | J:157167 |
| Mgi Id | MGI:4430129 | Doi | 10.4049/jimmunol.0900975 |
| Citation | Liu Z, et al. (2009) Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. J Immunol 183(10):6320-9 |
| abstractText | Th cell differentiation is precisely regulated by thousands of genes at different stages. In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during the course of Th2 differentiation, especially at the late stage. The up-regulated Dec2 can strongly promote Th2 development under Th2-inducing conditions, as evidenced by retrovirus-mediated gene transfer or transgenic manipulation. In addition, an enhancement of Th2 responses is also detectable in Dec2 transgenic mice in vivo. Conversely, RNA interference-mediated suppression of endogenous Dec2 could attenuate Th2 differentiation. Finally, we show that the enhanced Th2 development is at least in part due to substantial up-regulation of CD25 expression elicited by Dec2, thereby resulting in hyperresponsiveness to IL-2 stimulation. |
