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Allele : Tgfb2<tm1Doe> transforming growth factor, beta 2; targeted mutation 1, Thomas Doetschman

Primary Identifier  MGI:1888389 Allele Type  Targeted
Attribute String  Null/knockout Gene  Tgfb2
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
description  Homozygotes exhibit a "Peters'-like" anomaly instead of an Axenfeld-Reiger's and Peter's anomaly (J:73681).
molecularNote  Exon 6 was disrupted by the insertion of a neomycin selection cassette. The insertion introduced stop codons in all three reading frames. RT-PCR analysis showed an absence of normal message in homozygous mutant mice.
  • mutations:
  • Insertion
  • synonyms:
  • Tgfb2<->,
  • Tgfb2<->,
  • TGF-beta2-,
  • TGBbeta2-,
  • TGBbeta2-,
  • TGF-beta2-
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

54 Publication categories