| First Author | Sun Y | Year | 2013 |
| Journal | Cell Res | Volume | 23 |
| Issue | 11 | Pages | 1270-83 |
| PubMed ID | 23979021 | Mgi Jnum | J:336962 |
| Mgi Id | MGI:6852179 | Doi | 10.1038/cr.2013.116 |
| Citation | Sun Y, et al. (2013) MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines. Cell Res 23(11):1270-83 |
| abstractText | The vagus nerve can control inflammatory response through a 'cholinergic anti-inflammatory pathway', which is mediated by the alpha7-nicotinic acetylcholine receptor (alpha7nAChR) on macrophages. However, the intracellular mechanisms that link alpha7nAChR activation and pro-inflammatory cytokine production remain not well understood. In this study, we found that miR-124 is upregulated by cholinergic agonists in LPS-exposed cells and mice. Utilizing miR-124 mimic and siRNA knockdown, we demonstrated that miR-124 is a critical mediator for the cholinergic anti-inflammatory action. Furthermore, our data indicated that miR-124 modulates LPS-induced cytokine production by targeting signal transducer and activator of transcription 3 (STAT3) to decrease IL-6 production and TNF-alpha converting enzyme (TACE) to reduce TNF-alpha release. These results also indicate that miR-124 is a potential therapeutic target for the treatment of inflammatory diseases. |
