| First Author | Marubio LM | Year | 2004 |
| Journal | Neuroscience | Volume | 129 |
| Issue | 3 | Pages | 575-82 |
| PubMed ID | 15541879 | Mgi Jnum | J:94667 |
| Mgi Id | MGI:3513661 | Doi | 10.1016/j.neuroscience.2004.09.003 |
| Citation | Marubio LM, et al. (2004) Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors. Neuroscience 129(3):575-82 |
| abstractText | The nicotinic cholinergic system influences cognition, anxiety, locomotion, and addiction by acting upon nicotinic acetylcholine receptors (nAChRs). To date, there are 12 known neuronal mammalian nAChR subunits leading to a rich pharmacological diversity that is difficult to attribute to specific subunits. We generated alpha7-beta2 nAChR double mutant mice by breeding to investigate the effect of a minimal number of nAChRs in the CNS. These mice have been used to determine the role these receptor subunits play in a variety of behaviors. A battery of behavioral tests was used to determine the effect of the mutation in anxiety, locomotor activity, startle response, pre-pulse inhibition, motor coordination and learning and memory. Mice lacking both the alpha7 and the beta2 nAChR subunits displayed impaired learning and memory performance in a passive avoidance test and showed enhanced motor performance on the rotarod. |
