| First Author | Reichart U | Year | 2000 |
| Journal | Biochem Biophys Res Commun | Volume | 269 |
| Issue | 2 | Pages | 502-7 |
| PubMed ID | 10708583 | Mgi Jnum | J:61119 |
| Mgi Id | MGI:1354466 | Doi | 10.1006/bbrc.2000.2318 |
| Citation | Reichart U, et al. (2000) Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice. Biochem Biophys Res Commun 269(2):502-7 |
| abstractText | Non-insulin-dependent diabetes mellitus (type 2 diabetes) is known to be a polygenic and polyfactorial disorder. Here we describe the long-term examination of a transgenic mouse line showing the disruption of the leptin receptor (Lepr, Ob-R) gene caused by transgene insertion. The absence of the expression of the long isoform Ob-Rb uncovered a strong variation of the obesity and diabetes phenotype in the homozygous mutant mice of the outbred strain used. One part of the homozygous mice developed severe persistent early-onset obesity, whereas the other part developed cachexia after having shown initial obesity in the examination period up to 26 weeks p.p. The leptin-receptor-defective mice of this line might serve as a model for the investigation of genes modulating the development and mode of expression of diabetes. Copyright 2000 Academic Press. |
