| First Author | Yao PL | Year | 2017 |
| Journal | Immunology | Volume | 150 |
| Issue | 4 | Pages | 456-467 |
| PubMed ID | 27935639 | Mgi Jnum | J:246342 |
| Mgi Id | MGI:5923291 | Doi | 10.1111/imm.12699 |
| Citation | Yao PL, et al. (2017) Peroxisome proliferator-activated receptor-beta/delta modulates mast cell phenotype. Immunology 150(4):456-467 |
| abstractText | The peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) is known to have multiple anti-inflammatory effects, typically observed in endothelial cells, macrophages, T cells and B cells. Despite the fact that mast cells are important mediators of inflammation, to date, the role of PPARbeta/delta in mast cells has not been examined. Hence, the present study examined the hypothesis that PPARbeta/delta modulates mast cell phenotype. Bone-marrow-derived mast cells (BMMCs) and peritoneal mast cells from Pparbeta/delta+/+ mice expressed higher levels of high-affinity IgE receptor (FcepsilonRI) compared with Pparbeta/delta-/- mice. BMMCs from Pparbeta/delta+/+ mice also exhibited dense granules, associated with higher expression of enzymes and proteases compared with Pparbeta/delta-/- mice. Resting BMMCs from Pparbeta/delta+/+ mice secreted lower levels of inflammatory cytokines, associated with the altered activation of phospholipase Cgamma1 and extracellular signal-regulated kinases compared with Pparbeta/delta-/- mice. Moreover, the production of cytokines by mast cells induced by various stimuli was highly dependent on PPARbeta/delta expression. This study demonstrates that PPARbeta/delta is an important regulator of mast cell phenotype. |
