| First Author | Pittet JF | Year | 2001 |
| Journal | J Clin Invest | Volume | 107 |
| Issue | 12 | Pages | 1537-44 |
| PubMed ID | 11413161 | Mgi Jnum | J:70014 |
| Mgi Id | MGI:2136076 | Doi | 10.1172/JCI11963 |
| Citation | Pittet JF, et al. (2001) TGF-beta is a critical mediator of acute lung injury. J Clin Invest 107(12):1537-44 |
| abstractText | We have shown that the integrin alphavbeta6 activates latent TGF-beta in the lungs and skin. We show here that mice lacking this integrin are completely protected from pulmonary edema in a model of bleomycin-induced acute lung injury (ALI). Pharmacologic inhibition of TGF-beta also protected wild-type mice from pulmonary edema induced by bleomycin or Escherichia coli endotoxin. TGF-beta directly increased alveolar epithelial permeability in vitro by a mechanism that involved depletion of intracellular glutathione. These data suggest that integrin-mediated local activation of TGF-beta is critical to the development of pulmonary edema in ALI and that blocking TGF-beta or its activation could be effective treatments for this currently untreatable disorder. |
