| First Author | Cediel R | Year | 2006 |
| Journal | Eur J Neurosci | Volume | 23 |
| Issue | 2 | Pages | 587-90 |
| PubMed ID | 16420467 | Mgi Jnum | J:105536 |
| Mgi Id | MGI:3615754 | Doi | 10.1111/j.1460-9568.2005.04584.x |
| Citation | Cediel R, et al. (2006) Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness. Eur J Neurosci 23(2):587-90 |
| abstractText | It has been reported that mutations in the gene encoding human insulin-like growth factor-I (IGF-I) cause syndromic hearing loss. To study the precise role of IGF-I in auditory function and to hypothesize the possible morphological and electrophysiological changes that may occur in the human inner ear, we have analysed the auditory brainstem response in a mouse model of IGF-I deficiency. We show here that homozygous Igf-1(-/-) mice present an all-frequency involved bilateral sensorineural hearing loss. Igf-1(-/-) mice also present a delayed response to acoustic stimuli; this increases along the auditory pathway, indicating a contribution of the central nervous system to the hearing loss in Igf-1(-/-) mice. These results support the use of the Igf-1(-/-) mouse as a new model for the study of human syndromic deafness. |
