Primary Identifier | MGI:1926771 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Xrcc4 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Replacement of sequence encoding exon 3 of the Xrcc4 gene with a loxP-flanked neomycin cassette. This cassette was then removed by crossing mice with germline-Cre expressing mice to generate this allele containing a deletion of exon 3. Any potential transcript from this allele that spliced from exon 2 to exon 4 or 5 would harbor a frameshift mutation. |