| First Author | Enkhtuya R | Year | 2014 |
| Journal | Genes Cells | Volume | 19 |
| Issue | 4 | Pages | 350-8 |
| PubMed ID | 24520900 | Mgi Jnum | J:229339 |
| Mgi Id | MGI:5751644 | Doi | 10.1111/gtc.12135 |
| Citation | Enkhtuya R, et al. (2014) The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice. Genes Cells 19(4):350-8 |
| abstractText | The ultraviolet B (UVB) component of sunlight can cause severe damage to skin cells and even induce skin cancer. Growing evidence indicates that the UVB-induced signaling network is complex and involves diverse cellular processes. In this study, we investigated the role of c-Jun NH2 -terminal kinase-associated leucine zipper protein (JLP), a scaffold protein for mitogen-activated protein kinase (MAPK) signaling cascades, in UVB-induced apoptosis. We found that UVB-induced skin epidermal apoptosis was prevented in Jlp knockout (KO) as well as in keratinocyte-specific Jlp KO mice. Analysis of the repair of UVB-induced DNA damage over time showed no evidence for the involvement of JLP in this process. In contrast, UVB-stimulated p38 MAPK activation in the skin was impaired in both Jlp KO and keratinocyte-specific Jlp KO mice. Moreover, topical treatment of UVB-irradiated mouse skin with a p38 inhibitor significantly suppressed the epidermal apoptosis in wild-type mice, but not in Jlp KO mice. Our findings suggest that JLP in skin basal keratinocytes plays an important role in UVB-induced apoptosis by modulating p38 MAPK signaling pathways. This is the first study to show a critical role for JLP in an in vivo response to environmental stimulation. |
