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Publication : Induction of gene encoding FABP4 in Pten-null keratinocytes.

First Author  Tsuda M Year  2009
Journal  FEBS Lett Volume  583
Issue  8 Pages  1319-22
PubMed ID  19303874 Mgi Jnum  J:147986
Mgi Id  MGI:3843122 Doi  10.1016/j.febslet.2009.03.030
Citation  Tsuda M, et al. (2009) Induction of gene encoding FABP4 in Pten-null keratinocytes. FEBS Lett 583(8):1319-22
abstractText  Keratinocyte-specific Pten-null mice revealed distinct phenotypes, including epidermal and sebaceous gland hyperplasia. To determine the candidate genes that contribute to their phenotypes, we analyzed a comprehensive gene expression of Pten-null keratinocytes using microarray technology. Consequently, it was demonstrated that the most induced gene was adipocyte-specific fatty acid-binding protein (FABP4). Collectively, it is conceivable that the FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice.
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